HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilyl cyanide → HCID 68866956, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 1-Azabicyclo[2.2.2]oct-4-yl(di-2-thienyl)methanol | HCID 68865599 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 68866956 | HCID 68866956 | 34.1% |
Reaction Steps
Following the general procedure for cyano formation outlined in Example 1, 1-azabicyclo[2.2.2]oct-4-yl(di-2-thienyl)methanol (0.3065 g, 1.003 mmol), AlCl3 (0.661 g, 4.99 mmol) and TMSCN (0.66 mL, 4.95 mmol) in 1,2-dichloroethane (17.0 mL) were reacted to give the desired product (0.1073 g, 34.1%). EI-MS m/z 315 (M+) Rt (1.65 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07598267B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-d0d9d46f02de432dab68e1c2a4c4fe04 |
| Source note | uspto-grants-2009_10 |