Benzene, (3-bromopropoxy)- → HCID 11526589, compound

HRID 1817226Notes

Reaction equation

HRID 1817226 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:17]3[S:18][CH:19]=[CH:20][CH:21]=3)([C:12]3[S:13][CH:14]=[CH:15][CH:16]=3)[C:10]#[N:11])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[C:22]1([O:28][CH2:29][CH2:30][CH2:31][Br:32])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[Br-:32].[C:10]([C:9]([C:17]1[S:18][CH:19]=[CH:20][CH:21]=1)([C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)[C:4]12[CH2:7][CH2:8][N+:1]([CH2:31][CH2:30][CH2:29][O:28][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)([CH2:6][CH2:5]1)[CH2:2][CH2:3]2)#[N:11]

Participants

3

Reactant 2

HCID 68522Benzene, (3-bromopropoxy)-HCID 68866956HCID 68866956, compound

Product 1

HCID 11526589HCID 11526589, compoundYield 72%

Procedure

Following the general procedure outlined in Example 7, 1-azabicyclo[2.2.2]oct-4-yl(di-2-thienyl)acetonitrile (0.1073 g, 0.3412 mmol) and 3-bromopropyl phenyl ether (0.070 mL, 0.444 mmol) in 2CH3CN/3CHCl3 (6.5 mL) were reacted to give the desired product (0.1296 g, 72.0%). EI-MS m/z 449 (M+) Rt (2.17 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-d2de607b1a344a4d997d13b3fe2d1f5e
Source dataset
uspto-grants-2009_10
Patent number
US07598267B2

Reaction notes

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