2-Methylimidazole → HCID 10062359, compound

HRID 1817258Notes

Reaction equation

HRID 1817258 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH:5]=[N:4][CH:3]=1.[CH3:17][C:18]1[NH:19][CH:20]=[CH:21][N:22]=1>>[F:16][C:13]1[CH:14]=[CH:15][C:10]([CH2:9][NH:8][C:6]2[CH:5]=[N:4][CH:3]=[C:2]([N:19]3[CH:20]=[CH:21][N:22]=[C:18]3[CH3:17])[N:7]=2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 127492-MethylimidazoleHCID 40111420HCID 40111420, compound

Product 1

HCID 10062359HCID 10062359, compoundYield 23.5%

Procedure

In a procedure-analogous to example 2 reaction of 6-chloro-N-(4-fluorobenzyl)pyrazin-2-amine (150 mg, 0.63 mmol) and 2-methylimidazole (57 mg, 0.69 mmol) furnished the product (42 mg, 23%).

Sources & evidence

ORD record
ord-e722f83a8b6a4d43824aba880db977f2
Source dataset
uspto-grants-2009_10
Patent number
US07598272B2

Reaction notes

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