Benzimidazole → HCID 10471190, compound

HRID 1817264Notes

Reaction equation

HRID 1817264 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH:5]=[N:4][CH:3]=1.[N:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[NH:19][CH:18]=1>>[N:17]1([C:2]2[N:7]=[C:6]([NH:8][CH2:9][C:10]3[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=3)[CH:5]=[N:4][CH:3]=2)[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[CH:18]1

Participants

3

Reactant 2

HCID 5798BenzimidazoleHCID 40111420HCID 40111420, compound

Product 1

HCID 10471190HCID 10471190, compoundYield 53%

Procedure

In a procedure analogous to example 12, reaction of 6-chloro-N-(4-fluorobenzyl)pyrazin-2-amine (240 mg, 1.01 mmol) and benzimidazole (130 mg, 1.1 mmol) furnished the product (170 mg, 53%).

Sources & evidence

ORD record
ord-02d7bd3b16634506926a3f6da464321f
Source dataset
uspto-grants-2009_10
Patent number
US07598272B2

Reaction notes

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