Benzimidazole → HCID 10408302, compound

HRID 1817279Notes

Reaction equation

HRID 1817279 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([NH:10][C:11]2[CH:16]=[N:15][CH:14]=[C:13](Cl)[N:12]=2)[CH3:9])=[CH:4][CH:3]=1.[N:18]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[NH:20][CH:19]=1>>[N:18]1([C:13]2[N:12]=[C:11]([NH:10][C@H:8]([C:5]3[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=3)[CH3:9])[CH:16]=[N:15][CH:14]=2)[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[N:20]=[CH:19]1

Participants

3

Reactant 2

HCID 5798BenzimidazoleHCID 58934266HCID 58934266, compound

Product 1

HCID 10408302HCID 10408302, compoundYield 42%

Procedure

In a procedure analogous to example 25, reaction of N-[(1S)-1-(4-bromophenyl)ethyl]-6-chloropyrazin-2-amine (125 mg, 0.40 mmol) and benzimidazole (52 mg, 0.44 mmol) furnished the product (66 mg, 42%).

Sources & evidence

ORD record
ord-93cec0e386cc46e1999f9187f65f1d28
Source dataset
uspto-grants-2009_10
Patent number
US07598272B2

Reaction notes

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