Hydrogen Peroxide → 2,3,5-Trimethyl-1-oxidopyridin-1-ium

Participants

Reaction Conditions

Reaction Steps

To a stirred mixture of 2,3,5-collidine (10 g, 82.5 mmol) and glacial acetic acid (40 mL) was added hydrogen peroxide (30% solution, 20 mL, dropwise) at 65° C. The bath was heated to 90° C. for 1 hour, cooled to 65° C. and additional hydrogen peroxide (30% solution, 10 mL, dropwise) was added. The reaction mixture was heated at 90° C. until completion and cooled to ambient temperature. The solvent was removed under reduced pressure and the crude residue was used directly in the next step.

Provenance & Evidence