反应详情

To a solution of 1-(4-fluorobenzyl)-3-(phenylsulfinyl)piperidin-2-one (0.37 g, 1.11 mmol) in toluene (15 mL) was added solid Na2CO3 (2 g, 18.8 mmol). The reaction mixture was refluxed for about 6 hours. The resultant solution was filtered and concentrated under vacuum and the residue chromatographed on silica eluting with a gradient of 040% EtOAc/Hexanes to give the product as colorless glass.

1. temperatureThe reaction mixture was refluxed for about 6 hours
2. filtrationThe resultant solution was filtered
3. concentrationconcentrated under vacuum
4. customthe residue chromatographed on silica eluting with a gradient of 040% EtOAc/Hexanes