Phosphorus oxide (P4O10) → Methyl 5-methoxy-1,3-oxazole-2-carboxylate

Temperature

65 °C

To a warm (35-40° C.) suspension of phosphorous pentoxide (77.7 g, 109 mmol) in anhydrous acetonitrile (200 mL) was added methyl[(2-methoxy-2-oxoethyl)amino](oxo)acetate (19.19 g, 109.6 mmol). The reaction mixture was heated to 65° C., then stirred overnight at room temperature. The product mixture was cooled to 0° C. and carefully quenched with ice and brine keeping the reaction from generating an unsuitable exotherm. The resultant mixture was extracted with ethyl acetate (600 mL). The organic extract was washed with brine, dried with Na2SO4, then concentrated under vacuum. The residue was subjected to column chromatography on silica gel eluting with 100% CH2Cl2. The appropriate fractions were combined and concentrated to afford the title compound as a light yellow solid that was used without further purification.

1. temperatureTo a warm
2. temperatureThe product mixture was cooled to 0° C.
3. customcarefully quenched with ice and brine keeping
4. customthe reaction
5. extractionThe resultant mixture was extracted with ethyl acetate (600 mL)
6. extractionThe organic extract
7. washwas washed with brine
8. dry with materialdried with Na2SO4
9. concentrationconcentrated under vacuum
10. concentrationconcentrated

ORD record

ord-73364039a1844d138608c16198ebf673

Source dataset

uspto-grants-2009_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07598264B2