反应详情

To a solution of N-[6-(4-fluorobenzyl)-4-methoxy-5-oxo-5,6,7,8-tetrahydro-2,6-naphthyridin-1-yl]-N-methylmethanesulfonamide (0.35 g, 0.89 mmol) in CH2Cl2 (10 mL) was added mCPBA (1.08 g, 6.23 mmol) in portions. After stirring for 3.5 hours at reflux, the product mixture was cooled to room temperature, 1 mL of ethanol was added, and the solution was concentrated. The residue was partitioned between CHCl3 and saturated Na2SO3. The organic layer was extracted repeatedly with saturated sodium bicarbonate. The organic extract was dried with Na2SO4, filtered, and concentrated under vacuum to provide the crude title compound.

1. temperatureat reflux
2. concentrationthe solution was concentrated
3. customThe residue was partitioned between CHCl3 and saturated Na2SO3
4. extractionThe organic layer was extracted repeatedly with saturated sodium bicarbonate
5. extractionThe organic extract
6. dry with materialwas dried with Na2SO4
7. filtrationfiltered
8. concentrationconcentrated under vacuum