Hydrochloric Acid → HCID 69066186, compound

Participants

Reaction Steps

To a solution of ethyl 6-(4-fluorobenzyl)-4-methoxy-2-methyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate (1.15 g, 2.96 mmol) in 1:1:1 MeOH/H2O/THF (15 mL) was added LiOH (0.37 g, 8.88 mmol) and the solution was stirred for 2 hours. A solution of 1 N HCl (8.9 mL) was added, the solution was concentrated and CHCl3 and 10% KHSO4 were added. The layers were separated and the aqueous was extracted repeatedly. The combined organic layers were filtered and the solid collected. The remaining organic was dried over Na2SO4, filtered, combined with the collected solid and evaporated to give the crude product.

Provenance & Evidence