Bromoacetonitrile → HCID 54685976, compound

HRID 1817353Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][C:26]=1[F:27])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([OH:22])[C:10](=[O:21])[NH:11][C:12]=2[C:16]([N:18]([CH3:20])[CH3:19])=[O:17])[C:7]1=[O:23].Br[CH2:29][C:30]#[N:31]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][C:26]=1[F:27])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([OH:22])[C:10](=[O:21])[N:11]([CH2:29][C:30]#[N:31])[C:12]=2[C:16]([N:18]([CH3:20])[CH3:19])=[O:17])[C:7]1=[O:23]

Participants

Reactant 2

HCID 11534Bromoacetonitrile

HCID 66996844HCID 66996844, compound

Product 1

HCID 54685976HCID 54685976, compound

Procedure

The title compound was prepared in a manner similar to that described for 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-N,N-dimethyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxamide (Example 13, step 6), wherein bromoacetonitrile was employed in place of 2-iodopropane.

Sources & evidence

ORD record: ord-87e09b8df3b14adba73c37d945ac1106
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07598264B2

Reaction notes

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