Morpholine → HCID 54715152, compound

HRID 1817355Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[CH:32][C:33]=1[F:34])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([OH:29])[C:10](=[O:28])[N:11]([CH2:21][CH2:22][N:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[C:12]=2[C:16]([N:18]([CH3:20])[CH3:19])=[O:17])[C:7]1=[O:30].N1CC[O:38]CC1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[CH:32][C:33]=1[F:34])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([OH:29])[C:10](=[O:28])[N:11]([CH2:21][CH2:22][N:23]3[CH2:27][CH2:26][O:38][CH2:25][CH2:24]3)[C:12]=2[C:16]([N:18]([CH3:19])[CH3:20])=[O:17])[C:7]1=[O:30]

Participants

Reactant 2

HCID 8083Morpholine

HCID 54720512HCID 54720512, compound

Product 1

HCID 54715152HCID 54715152, compound

Procedure

The title compound was prepared in a manner similar to that described for 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-N,N-dimethyl-2-(2-pyrrolidin-1-ylethyl)-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxamide (Example 66), substituting pyrrolidine with morpholine. (ES MS M+1=507)

Sources & evidence

ORD record: ord-838f35f944e640cf8b01f7f01631f93c
Source dataset: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07598264B2

Reaction notes

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