HCID 57882340, compound → HCID 57882326, compound

HRID 1817357Notes

Reaction equation

HRID 1817357 reaction equation
FC1C=CC(CN2CCC3C(=C(O)C(=O)N(C(C)C)C=3C(N(C)C)=[O:18])C2=O)=CC=1.N[C:31]1[C:32](=[O:60])[N:33]([CH2:56][CH:57]([CH3:59])[CH3:58])[C:34]([C:51]([N:53]([CH3:55])[CH3:54])=[O:52])=[C:35]2[C:40]=1[C:39](=[O:41])[N:38]([CH2:42][C:43]1[CH:48]=[CH:47][C:46]([F:49])=[C:45](Cl)[CH:44]=1)[CH2:37][CH2:36]2>>[F:49][C:46]1[CH:47]=[CH:48][C:43]([CH2:42][N:38]2[CH2:37][CH2:36][C:35]3[C:40](=[C:31]([OH:18])[C:32](=[O:60])[N:33]([CH2:56][CH:57]([CH3:59])[CH3:58])[C:34]=3[C:51]([N:53]([CH3:54])[CH3:55])=[O:52])[C:39]2=[O:41])=[CH:44][CH:45]=1

Participants

3

Reactant 2

HCID 57882340HCID 57882340, compoundHCID 69068032HCID 69068032, compound

Product 1

HCID 57882326HCID 57882326, compound

Procedure

The title compound was prepared in a manner similar to that described for 6-(4-fluorobenzyl)-4-hydroxy-N,N-dimethyl-2-isopropyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxamide (Example 69), using 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-N,N-dimethyl-2-isobutyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxamide (Example 14). (ES MS M+1=416)

Sources & evidence

ORD record
ord-a139989f3cd14835b9ffd4892d9b715c
Source dataset
uspto-grants-2009_10
Patent number
US07598264B2

Reaction notes

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