N-Iodosuccinamide → HCID 54683933, compound

Participants

Reaction Steps

A mixture of 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-N,N-dimethyl-2-isopropyl-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxamide (43 mg, 0.10 mmol; Example 13) and N-iodosuccinamide (22 mg, 0.1 mmol) in trifluoromethanesulfonic acid at 0° C. was stirred for 10 minutes. The mixture was diluted with methanol and subjected to preparative HPLC purification on C-18 reverse stationary phase column eluting with a gradient of water—acetonitrile in the presence of 0.1% trifluoroacetic acid. Collection and lyophilization of appropriate fractions provided the titled compound.

Provenance & Evidence