tert-Butanol → HCID 131727649, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl 6-(3-chloro-4-fluorobenzyl)-4-methoxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylic acid (1.2 g, 3.04 mmol; Example 12, step 12), diisopropylethylamine (0.37 g, 3.65 mmol), and diphenylphosphoryl azide (1.00 g, 3.65 mmol) in a 1:1 mixture of dioxane and tert-butanol (30 mL) was heated in an oil bath 90° C. for 3 hours. The reaction mixture was concentrated under vacuum. The residue was subjected to column chromatography on silica gel eluting with 5% methanol in dichloromethane. Collection and concentration of appropriate fractions provided the titled compound.

Provenance & Evidence