Pyridine N-Oxide → 5-Bromo-2-(3-chloro-4-fluorobenzyl)-8-methoxy-2,3,4,6-tetrahydro-2,6-naphthyridine-1,7-dione

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Reaction Steps

5-Bromo-2-(3-chloro-4-fluorobenzyl)-8-methoxy-2,3,4,6-tetrahydro-2,6-naphthyridine-1,7-dione was prepared in a manner similar to that described in Example 12, step 7 to 9, except the oxidation of 5-bromo-2-(3-chloro-4-fluorobenzyl)-8-methoxy-3,4-dihydro-2,6-naphthyridin-1(2H)-one to the corresponding pyridine N-oxide was oxidized with hydrogen peroxide urea complex (Caron et al., Tetrahedron Lett., 2299, 2000).

Provenance & Evidence