Hydrogen Bromide → HCID 57882319, compound

Participants

Reaction Steps

A solution of 2-(3-chloro-4-fluorobenzyl)-5-ethyl-8-methoxy-6-methyl-2,3,4,6-tetrahydro-2,6-naphthyridine-1,7-dione (55 mg, 0.15 mmol) and 33% HBr in acetic acid (5 mL) in acetic acid (10 mL) was stirred at room temperature overnight. The product mixture was concentrated under vacuum. The residue was subjected to preparative reverse phase HPLC purification. Collection and lyophilization of appropriate fractions provide the titled compound.

Provenance & Evidence