Ammonium formate → HCID 11529279, compound

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Reaction Steps

A mixture of [3-(benzyloxy)phenyl]-(1-propyl-1H-indazol-3-yl)methanol (0.067 g, 0.18 mmol.), ammonium formate (0.09 g, 1.17 mmol) and 10% palladium on carbon (0.09 g) in 10 mL ethanol was heated at reflux for 18 hours. The reaction was filtered (celite) and the cake washed with excess ethanol. The filtrate was concentrated in vacuo. The crude product was purified by HPLC [column: silica gel 150×12 mm (Biotage) at 10 mL/min with methyl-t-butyl ether/hexane, gradient elution, 1:9 to 1:1 over 15 min) to give the title compound (0.018 g) as a white solid.

Provenance & Evidence