反应详情

温度

50 °C

To a solution of [4-(benzyloxy)phenyl](7-trifluoromethyl-1H-indazol-3-yl)methanone (0.372 g, 0.94 mmol) in 3 mL DMF was added in one portion sodium hydride (0.044 g, 1.1 mmol, 60% in oil). After the gas evolution ceased, cyclopentyl bromide (0.118 mL, 1.1 mmol) was added and the reaction was stirred at ambient to 50° C. for 24 hours. The cool reaction mixture was partitioned with EtOAc and 1 N HCl. The organic phase was washed with brine and dried (Na2SO4). The solvent was removed in vacuo. The resulting residue was purified by flash chromatography (silica gel, hexane-EtOAc, 9:1) to give 0.320 g of the title compound as a yellow solid.

1. customThe cool reaction mixture
2. customwas partitioned with EtOAc and 1 N HCl
3. washThe organic phase was washed with brine
4. dry with materialdried (Na2SO4)
5. customThe solvent was removed in vacuo
6. customThe resulting residue was purified by flash chromatography (silica gel, hexane-EtOAc, 9:1)