Isopropyl iodide → [4-(benzyloxy)phenyl][1-isopropyl-7-(trifluoromethyl)-1H-indazol-3-yl]methanone

Participants

Reaction Conditions

Reaction Steps

To a solution of [4-(benzyloxy)phenyl](7-trifluoromethyl-1H-indazol-3-yl)methanone (0.20 g, 0.5 mmol) in 3 mL DMF was added in one portion sodium hydride (0.020 g, 0.5 mmol, 60% in oil). After the gas evolution ceased, 2-iodopropane (0.075 mL, 0.75 mmol) was added and the reaction was stirred at ambient to 50° C. for 24 hours. The cool reaction mixture was partitioned with EtOAc and 1 N HCl. The organic phase was washed with brine and dried (Na2SO4). Removal of the solvent in vacuo provided 0.18 g of the title compound which was used directly in the following step.

Provenance & Evidence