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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1817497Generated: October 30, 2026

[4-(benzyloxy)phenyl][1-isopropyl-7-(trifluoromethyl)-1H-indazol-3-yl]methanone → HCID 11494004, compound

https://huagongshe.com/reaction/1817497

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[4-(benzyloxy)phenyl][1-isopropyl-7-(trifluoromethyl)-1H-indazol-3-yl]methanoneHCID 69061008—
CatalystPalladiumHCID 23938—
SolventCyclohexene ethanolHCID 18676862—
ProductHCID 11494004HCID 1149400498.2%

Reaction Conditions

Temperature70 °C

Reaction Steps

A mixture of [4-(benzyloxy)phenyl][1-isopropyl-7-(trifluoromethyl)-1H-indazol-3-yl]methanone (0.17 g, 0.38 mmol) and 10% palladium on carbon (0.10 g) in 10 mL ethanol/cyclohexene (3:1, v/v) was heated at 70° C. for 0.5 hours. The catalyst was filtered (celite) and the filtrate concentrated in vacuo to give crude product. The residue was crystallized from Et2O/hexane to give 0.130 g of product as a white solid

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07598286B2
Source datasetuspto-grants-2009_10
ORD IDord-adb193b8e35d4d2092b370899e3c5871
Source noteuspto-grants-2009_10