HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphosphate → [1,1-difluoro-2-[(2S,5R)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]ethyl]-[hydroxy(phosphonooxy)phosphoryl]oxy-phosphinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphosphate | HCID 3440921 | — |
| Reactant | [[[[1,1-difluoro-2-[(2S,5R)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]ethyl]-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]amino]phosphonic acid | HCID 5279011 | — |
| Reactant | Tributyl ammonium pyrophosphate | HCID 21910867 | — |
| Reactant | HCID 178527063 | HCID 178527063 | — |
| Product | [1,1-difluoro-2-[(2S,5R)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]ethyl]-[hydroxy(phosphonooxy)phosphoryl]oxy-phosphinic acid | HCID 5279009 | — |
Reaction Steps
Following the procedure for the compound 63, starting from 102 mg (0.19 mmol) of the product 61 from Step C, using tri(n-butyl)ammonium pyrophosphate (246 mg), after 18 h (25% of the target triphosphate in mixture with 41% of the imidazolyl phosphonate intermediate as judged by LCMS) 12 mg of the titled compound 64 was isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07598230B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-d81a8825a50c48a8b13c2c9392e2db03 |
| Source note | uspto-grants-2009_10 |