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Ethanol → HCID 178509693、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Hydrazine | HCID 9321 | — |
| 反応物 | 1-(3-Cyanophenyl)-3-(dimethylamino)acrolein | HCID 5714073 | — |
| 生成物 | HCID 178509693 | HCID 178509693 | 84.7% |
反応手順
The 3-[(2E)-3-(dimethylamino)prop-2-enoyl]benzonitrile (0.600 g, 0.00300 mol) was dissolved in ethanol (20.0 mL, 0.342 mol) and hydrazine (0.56 mL, 0.018 mol) under an atmosphere of nitrogen was stirred at room temperature for 1.5 h. The reaction was concentrated in vacuo to give a dark product which was purified by FCC on silica gel, eluting with ethyl acetate-hexane 1:1 to give 3-(1H-pyrazol-3-yl)benzonitrile as an oil (0.430 g, 84%), LC/MS (M+H)+: 170.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07598257B2 |
| 出典データセット | uspto-grants-2009_10 |
| ORD ID | ord-5f06a2b137fd4f798a3dd8a57c670952 |
| 出典メモ | uspto-grants-2009_10 |