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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1817739Generated: October 30, 2026

Phenylboronic Acid → 2-Cyano-3-fluorobiphenyl

https://huagongshe.com/reaction/1817739

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenylboronic AcidHCID 66827—
Reactant2-Fluoro-6-iodobenzonitrileHCID 522722—
ReactantEthanol toluene waterHCID 86587398—
SolventWater 1,2-dimethoxyethaneHCID 18180031—
Product2-Cyano-3-fluorobiphenylHCID 23509652—

Reaction Steps

The desired productwas prepared by substituting 2-fluoro-6-iodobenzonitrile for Example 1A and phenylboronic acid for Example 1B in Example 1C. Additionally, toluene/EtOH/H2O (3:2:1) was substituted for DME/H2O as the solvent.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07598283B2
Source datasetuspto-grants-2009_10
ORD IDord-55a44797efbd4002902c143117c373d1
Source noteuspto-grants-2009_10