反应详情

温度

0 °C

At 0° C., 23 g of a 1:3.5 mixture of methyl 3-dibenzylaminocyclohexanoate and benzyl 3-dibenzylaminocyclohexanoate were added dropwise to a suspension of 4.4 g of LiAlH4 in 250 ml of diethyl ether. The suspension was stirred at 0° C. for 2 h and then quenched using 2 ml of EtOAc, and 10 ml of 10N KOH were added. 50 g of MgSO4 were then added and the suspension was filtered. The residue was digested with EtOAc for 2 h and filtered again. The filtrate was concentrated, giving the product as an oil. C21 H27NO (309.46), LCMS (ESI): 310.2 (MH+).

1. customquenched
2. additionwere added
3. addition50 g of MgSO4 were then added
4. filtrationthe suspension was filtered
5. waitThe residue was digested with EtOAc for 2 h
6. filtrationfiltered again
7. concentrationThe filtrate was concentrated