HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl propiolate → 7,7-dimethyl-7,8-dihydroquinoline-2,5(1H,6H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl propiolate | HCID 12182 | — |
| Reactant | 3-Amino-5,5-dimethyl-2-cyclohexen-1-one | HCID 136680 | — |
| Reactant | 5-Oxo-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile | HCID 1849967 | — |
| Product | 7,7-dimethyl-7,8-dihydroquinoline-2,5(1H,6H)-dione | HCID 13516379 | 78.5% |
Reaction Steps
In analogy to (Pettit, G. R.; Fleming, W. C.; Paull, K. D. J. Org. Chem. 1968, 33 (3) 1089-1092), 3-amino-5,5-dimethylcyclohex-2-en-1-one was reacted with ethyl propio-late to give the title compound as a light brown solid in 78.5% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07598384B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-43529e555611496dbaf7d858aba485d9 |
| Source note | uspto-grants-2009_10 |