Water → 2-Azepan-1-yl-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carbonitrile

Participants

Reaction Steps

A solution of 2-chloro-5-oxo-5,6,7,8-tetrahydro-quinoline-3-carbonitrile (0.07 g, 0.34 mmol), azepane (0.07 g, 0.7 mmol) and triethylamine (0.052 ml, 0.07 g, 0.07 mmol) in ethyl alcohol (3 ml) was heated at reflux for 5 h. Then water (10 ml) was added and the precipitated solid was filtered off and recrystallized from ethyl alcohol to give the title compound (0.035 g, 38%).

Provenance & Evidence