HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 86616218, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 4-(2-Methoxy-5-propylphenyl)-2-thiazolamine | HCID 4268467 | — |
| Reactant | (3S)-1-((tert-butoxy)carbonyl)piperidine-3-carboxylic acid | HCID 6951168 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86616218 | HCID 86616218 | 79.8% |
Reaction Steps
0.5 g of TBTU, 0.1 g of HOBT, 0.35 g of (S)-N-Boc-nipecotic acid and then 0.3 mL of DIPEA are added, at a temperature of 0° C., to a solution of 0.5 g of 4-(2-methoxy-5-propylphenyl)-1,3-thiazol-2-amine, obtained in preparation I.4, in 4 mL of DMF. The medium is stirred at room temperature for 3 hours and then diluted with EtOAc and washed 4 times with 10% Na2CO3 solution and then with saturated NaCl solution. After drying over MgSO4, the solution is concentrated and then purified by flash chromatography to give 0.56 g of a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07598392B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-91b4f0677a6b43caaa82f2460c96f96f |
| Source note | uspto-grants-2009_10 |