反应详情

温度

90 °C

To a solution of 1-chloro-4-(isopropylsulfonyl)benzene (Step B, 679 mg, 3.1 mmol) in sulfuric acid (3 mL) was added potassium nitrate (555 mg, 5.5 mmol) at 80° C. The mixture was stirred at 90° C. for 2 h. Ice water (5 mL) was added, and the mixture was extracted with ethyl acetate (25 mL) and washed with water (10 mL×2) and brine (10 mL). The organic extracts were dried over sodium sulfate and concentrated to afford the title compound (849 mg, containing ethyl acetate) as a white solid.

1. extractionthe mixture was extracted with ethyl acetate (25 mL)
2. washwashed with water (10 mL×2) and brine (10 mL)
3. dry with materialThe organic extracts were dried over sodium sulfate
4. concentrationconcentrated