Cyclopentylacetyl chloride → 2-(Cyclopentylmethyl)-1-(cyclopropylmethyl)-5-(isopropylsulfonyl)-1H-benzimidazole

HRID 1817858Notes

Reaction equation

HRID 1817858 reaction equation
[CH:1]1([CH2:6][C:7](Cl)=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:10][C:11]1[CH:16]=[C:15]([S:17]([CH:20]([CH3:22])[CH3:21])(=[O:19])=[O:18])[CH:14]=[CH:13][C:12]=1[NH:23][CH2:24][CH:25]1[CH2:27][CH2:26]1>>[CH:1]1([CH2:6][C:7]2[N:23]([CH2:24][CH:25]3[CH2:27][CH2:26]3)[C:12]3[CH:13]=[CH:14][C:15]([S:17]([CH:20]([CH3:22])[CH3:21])(=[O:19])=[O:18])=[CH:16][C:11]=3[N:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 3485182Cyclopentylacetyl chlorideHCID 688699912-Amino-1-(N-cyclopropylmethylamino)-4-(isopropylsulfonyl)benzene

Product 1

HCID 578840012-(Cyclopentylmethyl)-1-(cyclopropylmethyl)-5-(isopropylsulfonyl)-1H-benzimidazole

Procedure

The title compound was prepared according to the procedure described in Step C of Example 5 from cyclopentylacetyl chloride (Step B) and 2-amino-1-(N-cyclopropylmethylamino)-4-(isopropylsulfonyl)benzene (Step E of Example 1).

Sources & evidence

ORD record
ord-25db333d2d0c4de0835f563903ba5cd4
Source dataset
uspto-grants-2009_10
Patent number
US07598393B2

Reaction notes

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