2-Amino-1-(N-cyclopropylmethylamino)-4-(isopropylsulfonyl)benzene → 1-(Cyclopropylmethyl)-2-(1-methylcyclopentylmethyl)-5-(isopropylsulfonyl)-1H-benzimidazole

HRID 1817859Notes

Reaction equation

HRID 1817859 reaction equation
[CH3:1][C:2]1([CH2:7][C:8](Cl)=O)[CH2:6][CH2:5][CH2:4][CH2:3]1.[NH2:11][C:12]1[CH:17]=[C:16]([S:18]([CH:21]([CH3:23])[CH3:22])(=[O:20])=[O:19])[CH:15]=[CH:14][C:13]=1[NH:24][CH2:25][CH:26]1[CH2:28][CH2:27]1>>[CH:26]1([CH2:25][N:24]2[C:13]3[CH:14]=[CH:15][C:16]([S:18]([CH:21]([CH3:23])[CH3:22])(=[O:20])=[O:19])=[CH:17][C:12]=3[N:11]=[C:8]2[CH2:7][C:2]2([CH3:1])[CH2:6][CH2:5][CH2:4][CH2:3]2)[CH2:27][CH2:28]1

Participants

3

Reactant 2

HCID 688699912-Amino-1-(N-cyclopropylmethylamino)-4-(isopropylsulfonyl)benzeneHCID 86604770(1-Methylcyclopentyl)acetyl chloride

Product 1

HCID 578839881-(Cyclopropylmethyl)-2-(1-methylcyclopentylmethyl)-5-(isopropylsulfonyl)-1H-benzimidazole

Procedure

The title compound was prepared according to the procedure described in Step C of Example 5 from (1-methylcyclopentyl)acetyl chloride (Step A) and 2-amino-1-(N-cyclopropylmethylamino)-4-(isopropylsulfonyl)benzene (Step E of Example 1).

Sources & evidence

ORD record
ord-23203796bfef493093ec4f231dd7f763
Source dataset
uspto-grants-2009_10
Patent number
US07598393B2

Reaction notes

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