Aluminium lithium hydride → HCID 68874198, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of lithium aluminum hydride (391 mg, 8.3 mmol) in tetrahydrofuran (15 mL) was added a tetrahydrofuran solution of methyl 1-(cyclopropylmethyl)-2-(2,2-dimethylpropyl)-1H-benzimidazole-5-carboxylate (Step C, 990 mg, 3.3 mmol) at 0° C. The mixture was stirred at 0° C. for 3 h. The mixture was quenched with potassium fluoride and sodium sulfate decahydrate and filtered. The filtrate was concentrated and the residue was purified by column chromatography on silica gel (hexane:ethyl acetate=1:2 as eluent) to afford the title compound (573 mg, 64%) as red gum.

Provenance & Evidence