Tetrahydrofurfurylamine → 4-(Ethylsulfonyl)-2-nitro-N-(tetrahydrofuran-2-ylmethyl)aniline
Reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][CH3:12])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:13]([O-:15])=[O:14].[O:16]1[CH2:20][CH2:19][CH2:18][CH:17]1[CH2:21][NH2:22]>>[CH2:11]([S:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:22][CH2:21][CH:17]2[CH2:18][CH2:19][CH2:20][O:16]2)=[C:3]([N+:13]([O-:15])=[O:14])[CH:4]=1)(=[O:10])=[O:9])[CH3:12]Participants
3
Procedure
The title compound was prepared according to the procedure described in Step A of Example 5 from 1-chloro-4-(ethylsulfonyl)-2-nitrobenzene (Step C of Example 2) and 1-(tetrahydrofuran-2-yl)methanamine (tetrahydrofurfurylamine available from Acros Organics).
Sources & evidence
- ORD record
- ord-fa2820fc585849bfbd8fa70d4f32a0d9
- Source dataset
- uspto-grants-2009_10
- Patent number
- US07598393B2
Reaction notes
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