HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Chloro-5-(ethylsulfonyl)-3-nitropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 178477663 | HCID 178477663 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 2-Chloro-5-(ethylsulfonyl)-3-nitropyridine | HCID 86241971 | — |
Reaction Steps
To a solution of 5-(ethylsulfonyl)-3-nitropyridin-2-ol (Step C, 575 mg, 2.5 mmol) in thionyl chloride (7 mL) was added N,N-dimethylformamide (one drop). The mixture was stirred under reflux for 2 h and concentrated to afford the crude title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07598393B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-1b091802f7314d1888aa95f9e03bdc57 |
| Source note | uspto-grants-2009_10 |