HCID 68870456, compound → HCID 53358426, compound

Participants

Reaction Steps

N-(5-(Ethylsulfonyl)-2-{[2-(trifluoromethoxy)ethyl]amino}phenyl)-2,2-dimethylpropanamide (187 mg, 0.47 mmol, step A) was dissolved in ethanol and 2N sodium hydroxide solution. The mixture was microwaved for 30 min at 140° C. The reaction mixture was quenched with water and extracted three times with ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulfate and filtered. The filtrate was evaporated under reduced pressure. The residue was purified by PTLC (hexane:acetone=3:1 as eluent) to afford the title compound (60 mg, 34%) as a yellow oil.

Provenance & Evidence