Ammonium Chloride → HCID 43115327, compound

Participants

Reaction Steps

A mixture of 4-bromo-N-(cyclopropylmethyl)-2-nitroaniline (Step A, 1.7 g, 6.2 mmol), iron (1.7 g, 31.2 mmol) and ammonium chloride (33 mg, 0.62 mmol) in ethanol (18 mL) and water (6 mL) was stirred under reflux for 4 h. After cooling to room temperature, the mixture was filtered and the filtrate was concentrated. The residue was dissolved in ethyl acetate (40 mL) and the mixture was washed with water containing aqueous ammonia. The organic layer was separated, dried over sodium sulfate and concentrated to afford the title compound (1.48 g, 98%) as a brown oil.

Provenance & Evidence