HCID 68873297, compound → HCID 58513576, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-{5-bromo-2-[(cyclopropylmethyl)amino]phenyl}-2,2-dimethylpropanamide (step A, 1.41 g, 4.34 mmol) and p-toluenesulfonic acd monohydrate (825 mg, 4.34 mmol) in toluene (50 mL) was stirred at 120° C. for 20 h. After cooling to room temperature, the mixture was quenched with sodium hydrogencarbonate aqueous solution. The organic layer was separated. The aqueous layer was extracted with ethylacetate. The combined organic layers were washed with brine, dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=10:1 as eluent) to afford the title compound (1.40 g, quantum yield) as a light brown oil.

Provenance & Evidence