8-Hydroxyquinoline → HCID 66918112, compound

Participants

Reaction Steps

2-(bromomethyl) naphthalene (663 mg, 3 mmol) was added to a stirred mixture of 8-hydroxy quinoline (435 mg, 3 mmol), K2CO3 (621 mg, 4.5 mmol) in acetone (20 ml) at room temperature. The reaction mixture was stirred at rt over weekend and then partitioned between EtOAc and water. Water layer was extracted with EtOAc (2×100 ml). The combined organic phase was washed with water (2×100 ml), brine and dried over sodium sulfate. After removal of solvent, the residue was washed with ether to give 650 mg of compound I-81. 1H-NMR (500 MHz, CDCl3).

Provenance & Evidence