Potassium Carbonate → HCID 66917719, compound

Participants

Reaction Steps

Synthesis of (3-Naphthalen-2-ylmethyl-2-oxo-2,3-dihydro-benzooxazol-4-yloxy)-acetic acid tert-butyl ester, I-88. A mixture of compound I-87 (140 mg, 0.48 mmol), tert-butyl bromoacetate (136 mg, 0.7 mmol) and K2CO3 (95 mg, 0.7 mmol) in acetone (10 ml) and DMF (5 ml) was stirred at rt over night and then partitioned between EtOAc and water. Water layer was extracted with EtOAc. The combined organic phase was washed with water, brine and dried over sodium sulfate. After removal of solvent, 160 mg of compound I-88 was obtained. 1H-NMR (500 MHz, CDCl3).

Provenance & Evidence