反应详情

A mixture of 2-amino-3-nitro-phenol (1.54 g, 0.01 mol), benzyl bromide (1.71 g, 0.01 mol) and K2CO3 (1.54 g, 0.011 mol) in DMF (5.0 mL) was stirred at room temperature. After 20 h, reaction mixture was diluted with water (100 mL) and extracted with EtOAc (100 mL×3). Combined organic layers were washed with 2N NaOH (20 mL×3), water (100 mL), brine (100 mL), dried over anhydrous sodium sulfate and concentrated to afford 2-Benzyloxy-6-nitro-phenylamine, I-107 (2.01 g).

1. customreaction mixture
2. extractionextracted with EtOAc (100 mL×3)
3. washCombined organic layers were washed with 2N NaOH (20 mL×3), water (100 mL), brine (100 mL)
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated