反应详情

温度

90 °C

To a solution of 2-Benzyloxy-6-nitro-phenylamine (I-107, 1.52 g, 0.0062 mol) in acetic anhydride (1.27 g, 0.0125 mol), 4 drops of conc. H2SO4 was added at room temperature and stirred for one minute and then the reaction flak was immersed in an oil bath maintained at 90° C. After 2 minutes, the solidified reaction mixture was taken in water (20 mL) and filtered the solid. Solid was further washed with water (20 mL×2) and dried under high vacuum to afford N-(2-benzyloxy-6-nitro-phenyl)acetamide, I-108 (1.59 g).

1. customthe reaction flak was immersed in an oil bath
2. waitAfter 2 minutes
3. filtrationfiltered the solid
4. washSolid was further washed with water (20 mL×2)
5. customdried under high vacuum