HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium cyanoborohydride → HCID 66922525, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 6,7-difluoro-2,3-dihydro-1H-inden-1-one | HCID 58950914 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 66922525 | HCID 66922525 | — |
Reaction Steps
6,7-Difluoro-1-indanone (6.000 g, 35.70 mmol), NaBH3CN (15.70 g, 0.25 mol) and NH4OAc (82.60 g, 1.07 mol) in isopropanol were reacted according to the protocols as outlined in general procedure C to give the title amine. Spectroscopic data: 1H NMR (300 MHz, CDCl3) δ 1.7 (br s, 2H), 1.78-1.90 (m, 1H), 2.44-2.57 (m, 1H), 2.72-2.87 (m, 1H), 2.95-3.09 (m, 1H), 4.7 (t, 1H, J=6.7 Hz), 6.86-7.00 (m, 2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07598417B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-6d493555de854254bab6d008b10f6931 |
| Source note | uspto-grants-2009_10 |