HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ls-104
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-(3,4-Dihydroxy-phenyl)-2-propenal | HCID 443034 | — |
| Reactant | N-(cyanoacetyl)benzylamide | HCID 178511179 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ls-104 | HCID 9861871 | 68% |
Reaction Steps
To 3,4-dihydroxycinnamaldehyde A12 (example 59) (32 mg, 0.2 mmol) and amide A3 (Example 4) (32 mg, 0.2 mmol) in 8 mL of ethanol 40 μl of piperidine was added and the mixture was kept at room temperature for 1 h. 2N HCl and water were added and the precipitated solid was recrystallized from ethanol-water to give 44 mg (68%) of an orange solid. The analytical data were identical to the compound prepared as described in Example 8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07598419B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-786fe6528f3b4d7cb2f7f1c74206825d |
| Source note | uspto-grants-2009_10 |