反应详情

5% Palladium on carbon (14 mg) was added to a suspension of N-benzyl-5-nitronaphthalene-1-carboxamide (128.0 mg, 0.418 mmol) in methanol (2.5 ml). The mixture was stirred at room temperature for 2 hours, under hydrogen atmosphere. After the palladium on carbon was filtered off, the filtrate was concentrated. The residue was solidified by a mixture of isopropyl ether: ethyl acetate (1:1), and the resulting solid was washed with isopropyl ether and dried to give the title compound as a light yellow solid (102 mg, 88.7%).

1. filtrationAfter the palladium on carbon was filtered off
2. concentrationthe filtrate was concentrated
3. additionThe residue was solidified by a mixture of isopropyl ether: ethyl acetate (1:1)
4. washthe resulting solid was washed with isopropyl ether
5. customdried