Isoamyl Alcohol → HCID 57884134, compound

Participants

Reaction Steps

2-Fluoro-nicotinic acid (84.7 mg, 0.600 mmol, 3-methyl-butan-1-ol (52.9 mg, 0.600 mmol) and potassium bis(trimethylsilyl)amide (478 mg, 2.40 mmol) were combined in 0.6 mL of N,N-dimethylformamide and subjected to microwave irradiation for 3 minutes at 180° C. [2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amine (117 mg, 0.600 mmol) and O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (304 mg, 0.800 mmol) was added and the solution was allowed to stir for 16 hours. The mixture was then purified by reverse phase preparative liquid chromatography to yield the pure product (1.5 mg, 0.0039 mmol, 0.65%) ESI-MS m/z calc. 386.2, found 387.4 (M+1)+. Retention time of 2.98 minutes.

Provenance & Evidence