HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminomethyltetrahydropyran → (7-Bromo-3-nitroquinolin-4-yl)(tetrahydropyran-4-ylmethyl)amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminomethyltetrahydropyran | HCID 2773210 | — |
| Reactant | 7-Bromo-4-chloro-3-nitroquinoline | HCID 21984361 | — |
| Product | (7-Bromo-3-nitroquinolin-4-yl)(tetrahydropyran-4-ylmethyl)amine | HCID 21984259 | 94.3% |
Reaction Steps
The method described in Part E of Examples 431-436 was used to treat 7-bromo-4-chloro-3-nitroquinoline (12.43 g, 43.45 mmol) with C-(tetrahydropyran-4-yl)methylamine (10 g, 87 mmol) to provide 15.0 g of (7-bromo-3-nitroquinolin-4-yl)(tetrahydropyran-4-ylmethyl)amine as a bright yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07598382B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-a9680f15ebc045888aa902883f7f2284 |
| Source note | uspto-grants-2009_10 |