HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-((3-Bromophenylamino)methylene)-2,2-di-methyl-1,3-dioxane-4,6-dione → 5-Bromoquinolin-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-((3-Bromophenylamino)methylene)-2,2-di-methyl-1,3-dioxane-4,6-dione | HCID 17252219 | — |
| Solvent | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| Product | 5-Bromoquinolin-4-ol | HCID 178418724 | — |
| Product | HCID 178418765 | HCID 178418765 | — |
Reaction Steps
5-[(3-Bromophenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (32.6 g, 0.100 mol) was heated at 250° C. in DOWTHERM A heat transfer fluid for one hour, and then the reaction was allowed to cool to ambient temperature. A precipitate formed upon cooling and was isolated by filtration and washed with diethyl ether to provide 7-bromoquinolin-4-ol and 5-bromoquinolin-4-ol in a 2:1 ratio.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07598382B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-177c410e574b43229fcfd04d139072cd |
| Source note | uspto-grants-2009_10 |