Methyl iodide → HCID 57883721, compound

HRID 1818302Notes

Reaction equation

HRID 1818302 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:14][C:15]([N:17]([CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[O:16])[S:9][C:10]=1[S:11][C:12]#N)=[O:5])[CH3:2].CI>>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:14][C:15]([N:17]([CH:24]2[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]2)[CH:18]2[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]2)=[O:16])[S:9][C:10]=1[S:11][CH3:12])=[O:5])[CH3:2].[CH:24]1([N:17]([CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[C:15](=[O:16])[NH:14][C:8]2[S:9][C:10]([S:11][CH3:12])=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 86611186HCID 86611186, compound

Product 2

HCID 57883721HCID 57883721, compoundHCID 86611185HCID 86611185, compound

Procedure

2-(3,3-Dicyclohexyl-ureido)-5-methylsulfanyl-thiazole-4-carboxylic acid ethyl ester was prepared as described in general procedure (H) using 2-(3,3-dicyclohexyl-ureido)-5-thiocyanato-thiazole-4-carboxylic acid ethyl ester and methyl iodide. Hydrolysis using general procedure (F) gave the title compound.

Workup

  1. customHydrolysis

Sources & evidence

ORD record
ord-1a46e4332afe418f9db0b3c064aeb8b4
Source dataset
uspto-grants-2009_10
Patent number
US07598391B2

Reaction notes

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