5-Aminothiazole 2-mercaptoacetic acid ethyl ester → HCID 178461388, compound

HRID 1818315Notes

Reaction equation

HRID 1818315 reaction equation
C([O:3][C:4](=[O:30])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([CH:23]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[C@H:16]2[CH2:21][CH2:20][C@H:19]([CH3:22])[CH2:18][CH2:17]2)=[O:14])=[N:9][CH:8]=1)C.C1(N[C@H]2CC[C@H](C)CC2)CCCCCC1.NC1SC=NC=1.C(OC(=O)CS)C>>[CH:23]1([N:15]([C@H:16]2[CH2:21][CH2:20][C@H:19]([CH3:22])[CH2:18][CH2:17]2)[C:13](=[O:14])[NH:12][C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:30])=[O:3])=[CH:8][N:9]=2)[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]1

Participants

4

Reactant 3

HCID 866111945-Aminothiazole 2-mercaptoacetic acid ethyl esterHCID 178461296HCID 178461296, compoundHCID 178473157HCID 178473157, compound

Product 1

HCID 178461388HCID 178461388, compound

Procedure

{2-[3-Cycloheptyl-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid ethyl ester prepared as described in general procedures (A) and (B) using cycloheptyl-(trans-4-methyl-cyclohexyl)-amine and 5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound.

Workup

  1. customHydrolysis

Sources & evidence

ORD record
ord-1c454b3c9fa54776b5914a01cc4b65e9
Source dataset
uspto-grants-2009_10
Patent number
US07598391B2

Reaction notes

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