Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1818355생성일: 2026년 10월 25일
1,1'-Carbonyldiimidazole → 4-[3-(5-Formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester
https://huagongshe.com/reaction/1818355
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 2-Amino-1,3-thiazole-5-carbaldehyde | HCID 2737798 | — |
| 반응물 | 4-(4-Methyl-cyclohexylamino)-piperidine-1-carboxylic acid tert-butyl ester | HCID 43652146 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-[3-(5-Formyl-thiazol-2-yl)-1-(4-methyl-cyclohexyl)-ureido]-piperidine-1-carboxylic acid tert-butyl ester | HCID 57883803 | 357.1% |
반응 단계
Prepared in a manner similar to general procedure (C) using 5-formyl-2-aminothiazole (1.88 g, 14.6 mmol), 4-(4-methyl-cyclohexylamino)-piperidine-1-carboxylic acid tert-butyl ester (4.32 mg, 14.6 mmol), catalytic DMAP, CDI (2.60 g, 1.1 mmol) and THF with heating to 65° C. afforded 1.77 g (27%) of the desired product after purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07598391B2 |
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| 출처 데이터셋 | uspto-grants-2009_10 |
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| ORD ID | ord-83cfa42c3780463db735501651468f6f |
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| 출처 메모 | uspto-grants-2009_10 |
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